By Medifit Biologicals

 

VERRUCOUS CARCINOMA

 

VERRUCOUS CARCINOMA DEFINITION

Verrucous carcinoma is a diffuse, papillary, non-metastasizing, well-differentiated malignant neoplasm of the oral epithelium.

 

VERRUCOUS CARCINOMA CAUSES:

Etiology

Verrucous carcinoma commonly occurs in people with tobacco chewing and snuff dipping habits.

Clinical features:

Age: The tumors usually affects individuals over 60 years of age.

Sex: Predominantly affects males.

Presentations:

  • Clinically verrucous carcinoma presents a slow growing, exophytic, papillary growth, having a white pebbly surface.
  • The surface of the lesion is sometimes ‘Warty’ and it shows multiple rauge-like folds with deep clefts in between
  • In verrucous carcinoma majority of the lesions are exophytic in nature however, there can be few lesions which are of invasive into the underlying tissue including bone.

Histopathology:

  • The hyperplastic epithelium often exhibits a papillary surface, being covered by a thick layer of para-keratin
  • Massively enlarged, bulb like, acanthotic rete rides are seen which often invaginate into the underlying connective tissue stroma.
  • All the bulbous rete-ridges of the epithelium tend to project into the underlying connective tissue at more or less the same level and this is knowing as “pushing margin”
  • Formation of epithelial pearls and micro cysts are often seen in verrucous carcinoma
  • The basement membrane is almost always intact

VERRUCOUS CARCINOMA DIFFERENTIAL DIAGNOSIS:

  • Papillary hyperplasia
  • Verrucous leukoplakia
  • Pyostomatitis vegetans
  • Squamous cell carcinoma
  • Chronic hyperplastic candidiasis
  • Pseudoepitheliomatous hyperplasia

 

VERRUCOUS CARCINOMA TREATMENT:

Surgical excision or laser therapy. Prognosis is good

 

By Medifit Biologicals

www.medifitbiologicals.com