SPINDLE CELL CARCINOMA
SPINDLE CELL CARCINOMA DEFINITION
Spindle cell carcinoma is a rare, unusual form of poorly differentiated squamous cell carcinoma. Consisting of elongated (spindle-shaped) epithelial cells.
SPINDLE CELL CARCINOMA CLINICAL FEATURES:
- Spindle cell carcinoma occurs primarily in males and the lesion frequently affects the lower lips, tongue and alveolar ridge.
- Clinically the lesion produces pain, ulceration and swelling, etc., however, the tumor may also exhibit a characteristic fleshy and polypoid growth pattern.
SPINDLE CELL CARCINOMA HISTOPATHOLOGY:
- Spindle cell carcinoma histologically reveals proliferation of numerous fustiform or spindle- shaped cells, resembling malignant fibroblasts and for this reason the lesion is often mistaken as a fibrosarcoma.
- The tumors cells often exhibit marked nuclear hyperchromatism, cellular pleomorphism, increased abnormal mitosis, etc.
- The malignant cells is spindle cell carcinoma exhibit minimum degrees of epithelial dysplasia with little or no keratin formation.
- The underlying connective tissue stroma reveals inflammatory cell infiltrations by lymphocytes, neutrophils and eosinophils, etc.
SPINDLE CELL CARCINOMA TREATMENT:
Spindle cell carcinomas are usually less aggressive than conventional squamous cell carcinomas and these lesions produce late metastasis. Surgical excision is the most effective mode of treatment.