By Medifit Biologicals

 

SPINDLE CELL CARCINOMA

 

SPINDLE CELL CARCINOMA DEFINITION

Spindle cell carcinoma is a rare, unusual form of poorly differentiated squamous cell carcinoma. Consisting of elongated (spindle-shaped) epithelial cells.

 

SPINDLE CELL CARCINOMA CLINICAL FEATURES:

  • Spindle cell carcinoma occurs primarily in males and the lesion frequently affects the lower lips, tongue and alveolar ridge.
  • Clinically the lesion produces pain, ulceration and swelling, etc., however, the tumor may also exhibit a characteristic fleshy and polypoid growth pattern.

 

SPINDLE CELL CARCINOMA HISTOPATHOLOGY:

  • Spindle cell carcinoma histologically reveals proliferation of numerous fustiform or spindle- shaped cells, resembling malignant fibroblasts and for this reason the lesion is often mistaken as a fibrosarcoma.
  • The tumors cells often exhibit marked nuclear hyperchromatism, cellular pleomorphism, increased abnormal mitosis, etc.
  • The malignant cells is spindle cell carcinoma exhibit minimum degrees of epithelial dysplasia with little or no keratin formation.
  • The underlying connective tissue stroma reveals inflammatory cell infiltrations by lymphocytes, neutrophils and eosinophils, etc.

 

SPINDLE CELL CARCINOMA TREATMENT:

Spindle cell carcinomas are usually less aggressive than conventional squamous cell carcinomas and these lesions produce late metastasis. Surgical excision is the most effective mode of treatment.

By Medifit Biologicals

www.medifitbiologicals.com