Neurofibroma are benign neural tissue neoplasms arising from the perineural fibroblasts.
They may occur either as solitary lesions in the oral cavity or as multiple lesions in association with fibromatosis.
NEUROFIBROMA CLINICAL FEATURES:
Age: neurofibroma may occur at any age, however most lesions are defected in adult life.
Sex: Both sexes are equally affected.
Site: intraorally, solitary neurofibroma often arise from the tongue, buccal mucosa, vestibule and lips, etc. These are more common on the skin surfaces.
- Clinically neurofibroma often present small, asymptomatic, submusocal mass with a multilobulated surface.
- Neurofibroma may also occur as central jaw lesions in relation to the mandible or maxilla and in such cases, they often produce a slow growing, painless, expansile, swelling of the jawbone.
- Pain and paresthesia are rarely present in these lesions.
- The nodular lesions vary in size from few millimeters to several centimeters in diameter, they are spherical in shape and often produce multiple, dome-shaped elevations of the skin.
NEUROFIBROMA RADIOGRAPHIC FEATURE:
Radiographically Neurofibroma of the jawbone usually produces a relatively well-demarcated, unilocular or multilocular radiolucent area, with expansion of the cortical palates and divergence of roots of the regional teeth.
- Neurofibroma, whether are occurring as solitary lesions or as part of the disease ‘multiple neurofibromatosis’, histologically they produce similar appearances.
- Histologically Neurofibroma exhibit numerous proliferating spindle-shaped cells resembling fibroblasts (neurofibroblasts).
- The neoplastic elements in neurofibroma fall to exhibit any specific cellular orientation pattern as seen in neurilemmoma. However, the ground substance sometime produce a myxoid appearance.
- The ‘café-au-lait’ pigmentations microscopically reveal basilar melanosis without any proliferation of melanocytes.
Solitary Neurofibroma are treated by surgical excision.