By Medifit Biologicals

MALIGNANT FIBROUS HISTIOCYTOMA

 

MALIGNANT FIBROUS HISTIOCYTOMA DEFINITION

Malignant fibrous histiocytoma are a group of aggressive malignant neoplasms, arising from the undifferentiated mesenchymal cells that differentiate along both fibroblastic and histiocytic pathways.

 

MALIGNANT FIBROUS HISTIOCYTOMA CLINICAL FEATURES:

Age: The diseases predominantly affects the younger people.

Sex: Both sexes are almost equally affected.

Site: Malignant fibrous histiocytomas are slightly uncommon neoplasm in the oral cavity. Whenever, they occur intraorally, they can be found in the maxillary antrum, tongue, buccal mucosa and maxillary or the mandibular bones, etc.

 

MALIGNANT FIBROUS HISTIOCYTOMA PRESENTATION:

  • The neoplasm clinically presents a fast enlarging, exophytic, lobulated and ulcerated growth of the oral cavity
  • Pain, hemorrhage, anesthesia or paresthesia of the neighboring structures is commonly seen.
  • Interosseouslesions often produce large, painful, expansile growth in the jawbone with mobility or spontaneous exfoliation of the regional teeth.
  • Facial asymmetry or gross facial disfigurement is often associated with the lesion.

 

MALIGNANT FIBROUS HISTIOCYTOMA RADIOGRAPHIC FEATURES:

  • Malignant fibrous histiocytoma radiographically presents a large, multilocular radiolucent area in the jawbone, with severe expansion and distortion of the cortical plates.
  • Destruction of interradicular bone and perforation of the cortical plates occur quite frequently.

 

MALIGNANT FIBROUS HISTIOCYTOMA HISTOPATHOLOGY:

  • Histopathology the neoplasm reveals actively proliferating, numerous polyhedral or oval shaped, malignant histiocytes and many spindle-shaped malignant fibroblast cells.
  • These malignant cells are often arranged in typical “cart-wheel” or “storiform” Pattern.

 

MALIGNANT FIBROUS HISTIOCYTOMA TREATMENT:

Wide surgical excision coupled with radiotherapy and chemotherapy.

 

By Medifit Biologicals

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