Liposarcoma are malignant neoplasm derived from cells that differentiate along adipose tissue lines and show some evidence of fat synthesis.
LIPOSARCOMA CLINICAL FEATURE:
- These are externally rare neoplasm especially in the oral cavity. In the head and neck region. They are more often encountered in the deep tissue of the neck.
- In the oral cavity. Lesions may develop from the lips, cheek, soft palate, floor of the mouth and maxilla or the mandible.
- Clinically Liposarcoma produce rapidly growing, painful, submucosal masses.
- Lesions are mostly lobulated and are soft or firm in consistency.
- These neoplasm are sometimes so soft and fluctuant.
- Histopathology Liposarcoma are more cellular lesions than lipomas and they consist of multiple number of foamy and ‘fat-containing’ malignant lipoblast cells.
- Many cells with ‘signet-ring’ appearance (vacuolated cytoplasm) are also found in these neoplasm.
- Some Liposarcoma are composed of poorly-differentiated round cells, with only focal evidence of cytoplasmic vacuolization.
- In Liposarcoma, the malignant lipoblast cells often produce large amount of fat within the tumor and this often leads to the myxoid appearance of the lesion.
Radical surgery and radiotherapy.