By Medifit Biologicals

 

LIPOSARCOMA

LIPOSARCOMA DEFINITION

Liposarcoma are malignant neoplasm derived from cells that differentiate along adipose tissue lines and show some evidence of fat synthesis.

 

LIPOSARCOMA CLINICAL FEATURE:

  • These are externally rare neoplasm especially in the oral cavity. In the head and neck region. They are more often encountered in the deep tissue of the neck.
  • In the oral cavity. Lesions may develop from the lips, cheek, soft palate, floor of the mouth and maxilla or the mandible.
  • Clinically Liposarcoma produce rapidly growing, painful, submucosal masses.
  • Lesions are mostly lobulated and are soft or firm in consistency.
  • These neoplasm are sometimes so soft and fluctuant.

 

LIPOSARCOMA HISTOPATHOLOGY:

  • Histopathology Liposarcoma are more cellular lesions than lipomas and they consist of multiple number of foamy and ‘fat-containing’ malignant lipoblast cells.
  • Many cells with ‘signet-ring’ appearance (vacuolated cytoplasm) are also found in these neoplasm.
  • Some Liposarcoma are composed of poorly-differentiated round cells, with only focal evidence of cytoplasmic vacuolization.
  • In Liposarcoma, the malignant lipoblast cells often produce large amount of fat within the tumor and this often leads to the myxoid appearance of the lesion.

 

LIPOSARCOMA TREATMENT:

Radical surgery and radiotherapy.

By Medifit Biologicals

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