By Medifit Biologicals

FIBROSARCOMA (MALIGNANT NEOPLASM OF MESENCHYMAL TISSUE)

 

FIBROSARCOMA (MALIGNANT NEOPLASM OF MESENCHYMAL TISSUE) DEFINITION

Fibrosarcoma are malignant neoplasm of the fibroblast cells, which often exhibit an aggressive and destructive behavior.

 

FIBROSARCOMA (MALIGNANT NEOPLASM OF MESENCHYMAL TISSUE) CLINICAL FEATURES:

Age: The neoplasm can occur at any age however the peak age of occurrence is between 35 to 55 years.

Sex: Both sexes are almost equally affected

Site:

  • Intraorally fibrosarcoma commonly arise from the check, tongue, gingiva, palate, floor of the mouth, maxillary sinus and pharynx, etc.
  • Intraosseous lesions, which occurs either periosteally or endosteally, frequently involve the jawbone.
  • Among the jaw lesions, mandible is affected far more commonly than maxilla.

 

FIBROSARCOMA (MALIGNANT NEOPLASM OF MESENCHYMAL TISSUE) CLINICAL PRESENTATION:

  • In the initial stages, fibrosarcoma mostly remains symptomatic and the condition often resembles a benign fibrous overgrowth.
  • In the later stages, the lesions becomes fast enlarging and within a short span of time, it gives rise to a large, painful, bulky, lobulated “fleshy” mass.
  • Pain and secondary infections are also common
  • Pain, anesthesia or paresthesia is often present
  • Fibrosarcoma are non-encapsulated tumors and they can be fixed to the underlying structures.

 

FIBROSARCOMA (MALIGNANT NEOPLASM OF MESENCHYMAL TISSUE) RADIOGRAPHIC FEATURE:

  • Fibrosarcoma of the jawbone radiographically produces a sharply defined radiolucent area with severe destruction of bone
  • Expansion and marked thinning of cortical bone, displacement of teeth and resorption of roots, etc., are common.

 

FIBROSARCOMA (MALIGNANT NEOPLASM OF MESENCHYMAL TISSUE) HISTOPATHOLOGY:

  • Active proliferation of numerous spindle-shaped, malignant fibroblast cells within the connective tissue stroma.
  • The malignant fibroblast cells often have a ‘tad-pole’ like appearance and most of the cells in fibrosarcoma are well differentiated.

 

FIBROSARCOMA (MALIGNANT NEOPLASM OF MESENCHYMAL TISSUE) DIFFERENTIAL DIAGNOSIS:

  • Malignant fibrous histiocytoma
  • Rhabdomyosarcoma
  • Liposarcoma
  • Neurogenic sarcoma
  • Nodular fasciitis

 

FIBROSARCOMA (MALIGNANT NEOPLASM OF MESENCHYMAL TISSUE) TREATMENT:

Radical surgical excision and chemotherapy is the treatment of choice. Radiotherapy is not effective. Prognosis is good because metastasis occurs only in few cases.

By Medifit Biologicals

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