By Medifit Biologicals

EWING’S SARCOMA

EWING’S SARCOMA DIFINITION

Ewing’s sarcoma is a highly malignant primary mesenchymal neoplasm of bone, which was first reported in 1921 by Ewing.

 

EWING’S SARCOMA CLINICAL FEATURE:

Incidence Ewing’s sarcoma constitute about 10% of all the malignant bone tumor.

Age: The neoplasm usually occurs in younger people, between the ages of 5 to 25 years

Sex: There is a slight male predominance (M: F ratio 60:40)

Site: Among the jaw lesions, mandible is affected more often than the maxilla.

Jaw lesions of Kaposi’s sarcoma are sometime metastatic in origin and in such cases, long bones are the primary sites of the neoplasm.

 

EWING’S SARCOMA PRESENTATION:

  • Patients with Ewing’s sarcoma usually have moderate fewer, leukocytosis and raised ESR, etc.
  • In the affected area of the jaw, rapid swelling occurs, which often associated with severe pain.
  • Expansion of the jawbone with paresthesia or anesthesia of the area can be frequently seen.
  • Unexplained loosening of the tooth is a very common feature of Ewing’s sarcoma.
  • In the later stages, the neoplasm develops surface ulceration.

 

EWING’S SARCOMA RADIOGRAPHIC FEATURES:

  • Radiographically Ewing’s sarcoma usually presents a radiolucent area in the bone with ill-defined margins.
  • Expansion and distortion of the cortical bones often occur along with widespread destruction of the alveolar bone.
  • In this disease the periosteum of the bone characteristically exhibits lamellar layering (an osteophytic reaction), which is known as “Onion-skin” appearance.

 

EWING’S SARCOMA DIFFERENTIAL DIAGNOSIS:

  • Garre,s Osteomyelitis
  • Lymphoma
  • Metastatic carcinoma
  • Leukemia
  • Myeloma
  • Mesenchymal chondrosarcoma
  • Small cell osteosarcoma

 

EWING’S SARCOMA TREATMENT:

Radiotherapy and multidrug chemotherapy surgery is occasionally attempted. 5 Year survival rate is only 10%.

 

By Medifit Biologicals

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