By Medifit Biologicals

 

BASAL CELL CARCINOMA

 

BASAL CELL CARCINOMA DEFINITON

Basal cell carcinoma is a common, locally aggressive, nonmetastasizing malignant neoplasm of the skin, which is usually composed of medullary pattern of basaloid cells.

 

BASAL CELL CARCINOMA CAUSES:

Clinical features:

Age: Basal cell carcinoma develops mostly in middle aged people, preferably in the 4th decade of life.

Sex: Males are most commonly affected than females

Presentation:

  • The neoplasm initiates as a slow growing, slightly elevated, small nodule.
  • It eventually develops into a central, crusted ulcer with an elevated, smooth rolled border.
  • The synonym “rodent ulcer” is given to this tumor since it makes a slow but relentless progress and increase in size by invading and destroying the adjoining tissues.

Histopathology:

  • Histopathology basal cell carcinoma is characterized by neoplastic proliferation of basaloid epithelial cells in the form of multiple solid islands.
  • The cells in the periphery of the tumor islands are columnar in shape and they often resemble basal layer of the oral epithelium with hyperchromatic nuclei.
  • The fibrous connective tissue stroma reveals varying degrees of cellularity and it contains large number of elastic fibers.

 

BASAL CELL CARCINOMA DIFFERENTIAL DIAGNOSIS:

The following lesions are included in the differential diagnosis of basal cell carcinoma:

  • Ameloblastoma
  • Salivary gland neoplasms
  • Squamous cell carcinoma.

 

BASAL CELL CARCINOMA TREATMENT:

Surgical Excision or electrocautery along with radiotherapy is the treatment of choice.

 

By Medifit Biologicals

www.medifitbiologicals.com